Regarding to IMS Health, sales of the product in the United States for 2009 were around $13 million. ‘Cardiovascular disease is certainly a leading reason behind death in the usa and APP’s approval of Metoprolol Tartrate Injection, USP, will provide an affordable, generic treatment for millions of patients who suffer a heart attack or acute myocardial infarction each year,’ said John Ducker, Chief and President Executive Officer of APP Pharmaceuticals. ‘Additionally, this approval additional expands APP’s growing Important Care product line.’ APP’s Metoprolol Tartrate Injection, USP is AP-rated, bar-coded and preservative-free, and is packaged in single dose 5 mg/5 mL vials..The experts believed variants in these genes might modify the risk or outcome of heart failure, or alter the response to heart failure therapy. Nothing unusual arrived of their search of the GRK2 gene. This was accomplished by acquiring genetic profiles greater than 2,000 volunteers in Cincinnati, Kansas Atlanta and City, including Americans of European descent and African Us citizens. Some of the volunteers experienced heart failure; others had ischemia; healthful volunteers produced up a third group. To deepen their understanding of the genetic variation, the researchers developed cell lines and developed genetically modified mice to predict the way the gene would function in humans.