Agent orange chemical, dioxin, attacks the mitochondria to cause cancer Experts with the University of Pennsylvania College of Veterinary Medicine have demonstrated the process by which the cancer-causing chemical dioxin episodes the cellular machinery, disrupts normal cellular function and promotes tumor progression. The team identified for the first time that mitochondria, the cellular sub-units that convert oxygen and nutrients into cellular fuel, are the target of tetrachlorodibenzodioxin, or TCDD. The analysis demonstrated that TCDD induces mitochondria-to-nucleus stress signaling, which induces the expression of cell nucleus genes associated with tumor metastasis and promotion. The mechanism the study team has described is directly relevant to understanding incidences of breasts and additional cancers in individual populations exposed to these chemical substances.Related StoriesBET protein family plays key role in regulation of regular neuronal advancement and functionNew analysis displays rare gene mutations cause half of most ASD casesOxytocin treatment enhances social, psychological and behavioral complications among small children with autism This is the first-time research shows proof for cross-chat between PGE2 and Wnt signalling in neuronal stem cells, according to the peer reviewed research published at Cell Communication and Signaling. Lead researcher and York U doctoral student Christine Wong adds, ‘Using real-period imaging microscopy, we established that higher degrees of PGE2 can transform Wnt-dependent behaviour of neural stem cells by increasing cell migration or proliferation.